The Bills answered the 49ers' field goal on their opening drive, which marked the first points Buffalo had allowed on an opening possession since Week 6 against the New York Jets. Buffalo responded with a 13-play, 65-yard drive that featured a key 7-yard run by quarterback Josh Allen on third-and-6. Davis capped the drive with a 5-yard touchdown run — his third rushing score of the season — to give the Bills a 7-3 lead.
With the touchdown, the 49ers allowed a rushing touchdown for the eighth consecutive game, tying the Jets for the longest active streak in the NFL (the Bengals have the longest streak at 10 games). This also marked San Francisco’s longest streak of allowing rushing touchdowns since 2020 (11 games).
After the 49ers missed a 45-yard field goal, the Bills quickly capitalized. On the very next play, running back James Cook took a handoff and sprinted down the right sideline for a 65-yard touchdown run, followed by a snow angel celebration. The score gave Buffalo a 14-3 lead and was the longest rush of Cook’s career — as well as the longest rushing touchdown by a Bills player since LeSean McCoy’s 75-yard touchdown in 2016.
The Bills added another score in the third quarter with an improvised play. On first-and-7 from the 49ers’ 7-yard line, Allen connected with wide receiver Amari Cooper, who was quickly surrounded by defenders. Cooper lateraled the ball back to Allen, who ran it into the end zone for a touchdown. Allen was credited with both a passing and receiving touchdown on the play, though he did not officially record a reception. The score put Buffalo up 28-3.
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